| 1 | 8 | ★ Highlighted: Rihanna, Umbrella: no.1 on four channels at once. Rihanna Feat. Jay-ZUmbrella | Chris Applebaum | Three Ft Giant |
| 2 | –not in the previous chart | My Chemical RomanceTeenagers | Marc Webb | DNA |
| 3 | 5 | Mutya BuenaReal Girl | Max & Dania | Bikini |
| 4 | 12 | Gym Class Heroes/P. StumpCupid’s Chokehold | Alan Ferguson | Anonymous |
| 5 | –not in the previous chart | Calvin HarrisThe Girls | Kim Gehrig | Academy |
| 6 | 1 | Beyonce/ShakiraBeautiful Liar | Jake Nava | Anonymous |
| 7 | 4 | Maroon 5Makes Me Wonder | John Hillcoat | Factory |
| 8 | –not in the previous chart | The Chemical BrothersDo It Again | Michael Haussman | HSI |
| 9 | –not in the previous chart | Justin TimberlakeLovestoned | Robert Hales | HSI |
| 10 | –not in the previous chart | CascadaA Never Ending Dream | Kevin Hewitt | Hewitt Prods |
| 11 | 6 | Booty LuvShine | Sarah Chatfield | Colonel Blimp |
| 12 | –not in the previous chart | Enrique InglesiasDo You Know? (Ping Pong...) | Jesse Terrero | Lotus Filmworks |
| 13 | –not in the previous chart | Avril LavigneWhen You’re Gone | Marc Klasfeld | Rockhard |
| 14 | 19 | Hello GoodbyeHere (In Your Arms) | Scott Culver | Instinct Productions |
| 15 | 3 | Linkin ParkWhat I’ve Done | Mr Hahn | Radical Media |
| 16 | –not in the previous chart | Kelly ClarksonNever Again | Joseph Kahn | HSI |
| 17 | –not in the previous chart | FergieBig Girls Don’t Cry | Anthony Mandker | Boxfesh |
| 18 | 32 | Bob Sinclar Feat. Cutee-BSound Of Freedom | Denis Thybaud | Cosa, Paris |
| 19 | –not in the previous chart | Gwen Stefani4 In The Morning | Sophie Muller | Oil Factory Inc |
| 20 | –not in the previous chart | Take ThatI’d Wait For Life | Sean De Sparengo | Therapy |
| 21 | –not in the previous chart | Natasha BedingfieldSoulmate | Mark Pellington | Merge@Crossroads |
| 22 | –not in the previous chart | James MorrisonOne Last Chance | Charles Mehling | Streetgang |
| 23 | 10 | Alex Gaudino/C. WatersDestination Calabria | Rani | Between The Eyes |
| 24 | –not in the previous chart | Kelly Rowland Feat. EveLike This | Mike Ruiz | DNA |
| 25 | 20 | Nelly FurtadoSay It Right | Rankin & Chris | HSI |
| 26 | –not in the previous chart | Ne-YoDo You | Melina | Black Dog |
| 27 | –not in the previous chart | ShapeshiftersPusher | tbc | tbc |
| 28 | –not in the previous chart | Armand Van HeldenNYC Beat | Youthclub | Flynn |
| 29 | –not in the previous chart | The KillersFor Reasons Unknown | Diane Martel | DNA |
| 30 | –not in the previous chart | Timbaland/Timberlake/FurtadoGive It To Me | James Cameron | Lightstorm Entertainment |
| 31 | –not in the previous chart | Masters At WorkWork | tbc | tbc |
| 32 | –not in the previous chart | EditorsSmokers At The Hospital Door | Arni & Kinski | HSI London |
| 33 | –not in the previous chart | The HoosiersWorried About Ray | Diamond Dogs | HSI London |
| 34 | –not in the previous chart | Robin ThickeLost Without U | Benny Boom | FM Rocks |
| 35 | 22 | The FrayOver My Head | Elliot Lester | tbc |
| 36 | 24 | Gwen Stefani Feat. AkonThe Sweet Escape | Joseph Kahn | HSI |
| 37 | –not in the previous chart | The FratellisOle Black ‘N’ Blue Eyes | Jon Yeo and John Sunter | Wonderland |
| 38 | –not in the previous chart | AkonDon’t Matter | Gil Green | Blink |
| 39 | –not in the previous chart | Nelly FurtadoIn God’s Hands | Jesse Dylan | Form TV |
| 40 | –not in the previous chart | Timbaland feat. Keri HilsonThe Way I Are | Shane Drake | Merge @ Crossroads |
| 41 | –not in the previous chart | CorenellKeep On Jumping | Robin Schmidt | Chrome |
| 42 | –not in the previous chart | Super Mal feat. LucianaBigger Than Big | Michael Baldwin | Red Rabbit |
| 43 | –not in the previous chart | The White StripesIcky Thump | The Malloys | HSI |
| 44 | 29 | Camille Jones Vs Fedde le GrandThe Creeps | Marcus Adams | Alchemy |
| 45 | –not in the previous chart | Simon WebbeRide The Storm | Max & Dania?? | Bikini |
| 46 | –not in the previous chart | Gareth GatesAngel On My Shoulder | JT | Draw |
| 47 | 21 | Christina AguileraCandyman | Matthew Rolston | HSI |
| 48 | –not in the previous chart | BeyoncéGreen Light | Melina/Beyonce | Black Dog |
| 49 | –not in the previous chart | Bobby Valentino feat. TimbalaAnonymous | Bernard Gourley | Immigrant Films |
| 50 | 9 | Ne-YoBecause Of You | Melina | Black Dog |